Olaf Schneewind

Biosciences Graduate Program Association
Publications
  1. Liesenborghs L, Meyers S, Lox M, Criel M, Claes J, Peetermans M, Trenson S, Vande Velde G, Vanden Berghe P, Baatsen P, Missiakas D, Schneewind O, Peetermans WE, Hoylaerts MF, Vanassche T, Verhamme P. Staphylococcus aureus endocarditis: distinct mechanisms of bacterial adhesion to damaged and inflamed heart valves. Eur Heart J. 2019 Mar 03. View in: PubMed

  2. Chateau A, Schneewind O, Missiakas D. Extraction and Purification of Wall-Bound Polymers of Gram-Positive Bacteria. Methods Mol Biol. 2019; 1954:47-57. View in: PubMed

  3. Schneewind O, Missiakas D. Sortases, Surface Proteins, and Their Roles in Staphylococcus aureus Disease and Vaccine Development. Microbiol Spectr. 2019 01; 7(1). View in: PubMed

  4. Chen X, Sun Y, Missiakas D, Schneewind O. Staphylococcus aureus Decolonization of Mice With Monoclonal Antibody Neutralizing Protein A. J Infect Dis. 2019 Feb 23; 219(6):884-888. View in: PubMed

  5. Mancini S, Oechslin F, Menzi C, Que YA, Claes J, Heying R, Veloso TR, Vanassche T, Missiakas D, Schneewind O, Moreillon P, Entenza JM. Marginal role of von Willebrand factor-binding protein and coagulase in the initiation of endocarditis in rats with catheter-induced aortic vegetations. Virulence. 2018; 9(1):1615-1624. View in: PubMed

  6. Bobrovskyy M, Willing SE, Schneewind O, Missiakas D. EssH Peptidoglycan Hydrolase Enables Staphylococcus aureus Type VII Secretion across the Bacterial Cell Wall Envelope. J Bacteriol. 2018 Oct 15; 200(20). View in: PubMed

  7. Winstel V, Missiakas D, Schneewind O. Staphylococcus aureus targets the purine salvage pathway to kill phagocytes. Proc Natl Acad Sci U S A. 2018 06 26; 115(26):6846-6851. View in: PubMed

  8. Yu W, Missiakas D, Schneewind O. Septal secretion of protein A in Staphylococcus aureus requires SecA and lipoteichoic acid synthesis. Elife. 2018 05 14; 7. View in: PubMed

  9. Sun Y, Emolo C, Holtfreter S, Wiles S, Kreiswirth B, Missiakas D, Schneewind O. Staphylococcal Protein A Contributes to Persistent Colonization of Mice with Staphylococcus aureus. J Bacteriol. 2018 05 01; 200(9). View in: PubMed

  10. Chateau A, Lunderberg JM, Oh SY, Abshire T, Friedlander A, Quinn CP, Missiakas DM, Schneewind O. Galactosylation of the Secondary Cell Wall Polysaccharide of Bacillus anthracis and Its Contribution to Anthrax Pathogenesis. J Bacteriol. 2018 03 01; 200(5). View in: PubMed

  11. Missiakas D, Schneewind O. Assembly and Function of the Bacillus anthracis S-Layer. Annu Rev Microbiol. 2017 09 08; 71:79-98. View in: PubMed

  12. Armitage JP, Becker A, Christie PJ, de Boer PAJ, DiRita VJ, Gourse RL, Henkin TM, Margolin W, Metcalf WW, Mullineaux CW, O'Toole GA, Parkinson JS, Schneewind O, Silhavy TJ, Stock AM, Zhulin IB. Classic Spotlights: Selected Highlights from the First 100 Years of the Journal of Bacteriology. J Bacteriol. 2017 07 01; 199(13). View in: PubMed

  13. Mitchell A, Tam C, Elli D, Charlton T, Osei-Owusu P, Fazlollahi F, Faull KF, Schneewind O. Glutathionylation of Yersinia pestis LcrV and Its Effects on Plague Pathogenesis. MBio. 2017 05 16; 8(3). View in: PubMed

  14. Callegan MC, Parkunan SM, Randall CB, Coburn PS, Miller FC, LaGrow AL, Astley RA, Land C, Oh SY, Schneewind O. The role of pili in Bacillus cereus intraocular infection. Exp Eye Res. 2017 06; 159:69-76. View in: PubMed

  15. Claes J, Liesenborghs L, Peetermans M, Veloso TR, Missiakas D, Schneewind O, Mancini S, Entenza JM, Hoylaerts MF, Heying R, Verhamme P, Vanassche T. Clumping factor A, von Willebrand factor-binding protein and von Willebrand factor anchor Staphylococcus aureus to the vessel wall. J Thromb Haemost. 2017 05; 15(5):1009-1019. View in: PubMed

  16. Yu W, Kim HK, Rauch S, Schneewind O, Missiakas D. Pathogenic conversion of coagulase-negative staphylococci. Microbes Infect. 2017 02; 19(2):101-109. View in: PubMed

  17. Oh SY, Lunderberg JM, Chateau A, Schneewind O, Missiakas D. Genes Required for Bacillus anthracis Secondary Cell Wall Polysaccharide Synthesis. J Bacteriol. 2017 01 01; 199(1). View in: PubMed

  18. Ohr RJ, Anderson M, Shi M, Schneewind O, Missiakas D. EssD, a Nuclease Effector of the Staphylococcus aureus ESS Pathway. J Bacteriol. 2017 01 01; 199(1). View in: PubMed

  19. Anderson M, Ohr RJ, Aly KA, Nocadello S, Kim HK, Schneewind CE, Schneewind O, Missiakas D. EssE Promotes Staphylococcus aureus ESS-Dependent Protein Secretion To Modify Host Immune Responses during Infection. J Bacteriol. 2017 01 01; 199(1). View in: PubMed

  20. Nygaard TK, Kobayashi SD, Freedman B, Porter AR, Voyich JM, Otto M, Schneewind O, DeLeo FR. Interaction of Staphylococci with Human B cells. PLoS One. 2016; 11(10):e0164410. View in: PubMed

  21. Missiakas D, Schneewind O. Staphylococcus aureus vaccines: Deviating from the carol. J Exp Med. 2016 08 22; 213(9):1645-53. View in: PubMed

  22. Schneewind O. Classic Spotlight: Studies on the Low-Calcium Response of Yersinia pestis Reveal the Secrets of Plague Pathogenesis. J Bacteriol. 2016 08 01; 198(15):2018. View in: PubMed

  23. Schneewind O. Classic Spotlight: Molecular Biology of Methicillin Resistance in Staphylococcus aureus. J Bacteriol. 2016 07 15; 198(14):1903. View in: PubMed

  24. Malachowa N, Kobayashi SD, Porter AR, Braughton KR, Scott DP, Gardner DJ, Missiakas DM, Schneewind O, DeLeo FR. Contribution of Staphylococcus aureus Coagulases and Clumping Factor A to Abscess Formation in a Rabbit Model of Skin and Soft Tissue Infection. PLoS One. 2016; 11(6):e0158293. View in: PubMed

  25. Kim HK, Falugi F, Missiakas DM, Schneewind O. Peptidoglycan-linked protein A promotes T cell-dependent antibody expansion during Staphylococcus aureus infection. Proc Natl Acad Sci U S A. 2016 May 17; 113(20):5718-23. View in: PubMed

  26. Thomer L, Schneewind O, Missiakas D. Pathogenesis of Staphylococcus aureus Bloodstream Infections. Annu Rev Pathol. 2016 05 23; 11:343-64. View in: PubMed

  27. Thomer L, Emolo C, Thammavongsa V, Kim HK, McAdow ME, Yu W, Kieffer M, Schneewind O, Missiakas D. Antibodies against a secreted product of Staphylococcus aureus trigger phagocytic killing. J Exp Med. 2016 Mar 07; 213(3):293-301. View in: PubMed

  28. Chan YG, Frankel MB, Missiakas D, Schneewind O. SagB Glucosaminidase Is a Determinant of Staphylococcus aureus Glycan Chain Length, Antibiotic Susceptibility, and Protein Secretion. J Bacteriol. 2016 Jan 25; 198(7):1123-36. View in: PubMed

  29. Liszewski Zilla M, Lunderberg JM, Schneewind O, Missiakas D. Bacillus anthracis lcp Genes Support Vegetative Growth, Envelope Assembly, and Spore Formation. J Bacteriol. 2015 Dec; 197(23):3731-41. View in: PubMed

  30. Lunderberg JM, Liszewski Zilla M, Missiakas D, Schneewind O. Bacillus anthracis tagO Is Required for Vegetative Growth and Secondary Cell Wall Polysaccharide Synthesis. J Bacteriol. 2015 Nov; 197(22):3511-20. View in: PubMed

  31. Thammavongsa V, Kim HK, Missiakas D, Schneewind O. Staphylococcal manipulation of host immune responses. Nat Rev Microbiol. 2015 Sep; 13(9):529-43. View in: PubMed

  32. Nguyen-Mau SM, Oh SY, Schneewind DI, Missiakas D, Schneewind O. Bacillus anthracis SlaQ Promotes S-Layer Protein Assembly. J Bacteriol. 2015 Oct; 197(19):3216-27. View in: PubMed

  33. Oh SY, Richter SG, Missiakas DM, Schneewind O. Glutamate Racemase Mutants of Bacillus anthracis. J Bacteriol. 2015 Jun; 197(11):1854-61. View in: PubMed

  34. Bagnoli F, Fontana MR, Soldaini E, Mishra RP, Fiaschi L, Cartocci E, Nardi-Dei V, Ruggiero P, Nosari S, De Falco MG, Lofano G, Marchi S, Galletti B, Mariotti P, Bacconi M, Torre A, Maccari S, Scarselli M, Rinaudo CD, Inoshima N, Savino S, Mori E, Rossi-Paccani S, Baudner B, Pallaoro M, Swennen E, Petracca R, Brettoni C, Liberatori S, Norais N, Monaci E, Bubeck Wardenburg J, Schneewind O, O'Hagan DT, Valiante NM, Bensi G, Bertholet S, De Gregorio E, Rappuoli R, Grandi G. Vaccine composition formulated with a novel TLR7-dependent adjuvant induces high and broad protection against Staphylococcus aureus. Proc Natl Acad Sci U S A. 2015 Mar 24; 112(12):3680-5. View in: PubMed

  35. Kim HK, Falugi F, Thomer L, Missiakas DM, Schneewind O. Protein A suppresses immune responses during Staphylococcus aureus bloodstream infection in guinea pigs. MBio. 2015 Jan 06; 6(1). View in: PubMed

  36. Thammavongsa V, Rauch S, Kim HK, Missiakas DM, Schneewind O. Protein A-neutralizing monoclonal antibody protects neonatal mice against Staphylococcus aureus. Vaccine. 2015 Jan 15; 33(4):523-6. View in: PubMed

  37. Liszewski Zilla M, Chan YG, Lunderberg JM, Schneewind O, Missiakas D. LytR-CpsA-Psr enzymes as determinants of Bacillus anthracis secondary cell wall polysaccharide assembly. J Bacteriol. 2015 Jan; 197(2):343-53. View in: PubMed

  38. Pauli NT, Kim HK, Falugi F, Huang M, Dulac J, Henry Dunand C, Zheng NY, Kaur K, Andrews SF, Huang Y, DeDent A, Frank KM, Charnot-Katsikas A, Schneewind O, Wilson PC. Staphylococcus aureus infection induces protein A-mediated immune evasion in humans. J Exp Med. 2014 Nov 17; 211(12):2331-9. View in: PubMed

  39. Zhang J, Liu H, Zhu K, Gong S, Dramsi S, Wang YT, Li J, Chen F, Zhang R, Zhou L, Lan L, Jiang H, Schneewind O, Luo C, Yang CG. Antiinfective therapy with a small molecule inhibitor of Staphylococcus aureus sortase. Proc Natl Acad Sci U S A. 2014 Sep 16; 111(37):13517-22. View in: PubMed

  40. Rauch S, Gough P, Kim HK, Schneewind O, Missiakas D. Vaccine protection of leukopenic mice against Staphylococcus aureus bloodstream infection. Infect Immun. 2014 Nov; 82(11):4889-98. View in: PubMed

  41. Claes J, Vanassche T, Peetermans M, Liesenborghs L, Vandenbriele C, Vanhoorelbeke K, Missiakas D, Schneewind O, Hoylaerts MF, Heying R, Verhamme P. Adhesion of Staphylococcus aureus to the vessel wall under flow is mediated by von Willebrand factor-binding protein. Blood. 2014 Sep 04; 124(10):1669-76. View in: PubMed

  42. Wang YT, Missiakas D, Schneewind O. GneZ, a UDP-GlcNAc 2-epimerase, is required for S-layer assembly and vegetative growth of Bacillus anthracis. J Bacteriol. 2014 Aug 15; 196(16):2969-78. View in: PubMed

  43. Kim HK, Missiakas D, Schneewind O. Mouse models for infectious diseases caused by Staphylococcus aureus. J Immunol Methods. 2014 Aug; 410:88-99. View in: PubMed

  44. Chan YG, Kim HK, Schneewind O, Missiakas D. The capsular polysaccharide of Staphylococcus aureus is attached to peptidoglycan by the LytR-CpsA-Psr (LCP) family of enzymes. J Biol Chem. 2014 May 30; 289(22):15680-90. View in: PubMed

  45. Deng FK, Zhang L, Wang YT, Schneewind O, Kent SB. Total chemical synthesis of the enzyme sortase A(?N59) with full catalytic activity. Angew Chem Int Ed Engl. 2014 Apr 25; 53(18):4662-6. View in: PubMed

  46. Schneewind O, Missiakas D. Genetic manipulation of Staphylococcus aureus. Curr Protoc Microbiol. 2014 Feb 06; 32:Unit 9C.3.. View in: PubMed

  47. Becker S, Frankel MB, Schneewind O, Missiakas D. Release of protein A from the cell wall of Staphylococcus aureus. Proc Natl Acad Sci U S A. 2014 Jan 28; 111(4):1574-9. View in: PubMed

  48. Schneewind O, Missiakas D. Lipoteichoic acids, phosphate-containing polymers in the envelope of gram-positive bacteria. J Bacteriol. 2014 Mar; 196(6):1133-42. View in: PubMed

  49. Tam C, Demke O, Hermanas T, Mitchell A, Hendrickx AP, Schneewind O. YfbA, a Yersinia pestis regulator required for colonization and biofilm formation in the gut of cat fleas. J Bacteriol. 2014 Mar; 196(6):1165-73. View in: PubMed

  50. Cheng AG, Missiakas D, Schneewind O. The giant protein Ebh is a determinant of Staphylococcus aureus cell size and complement resistance. J Bacteriol. 2014 Mar; 196(5):971-81. View in: PubMed

  51. Mahdavi A, Szychowski J, Ngo JT, Sweredoski MJ, Graham RL, Hess S, Schneewind O, Mazmanian SK, Tirrell DA. Identification of secreted bacterial proteins by noncanonical amino acid tagging. Proc Natl Acad Sci U S A. 2014 Jan 07; 111(1):433-8. View in: PubMed

  52. Thomer L, Becker S, Emolo C, Quach A, Kim HK, Rauch S, Anderson M, Leblanc JF, Schneewind O, Faull KF, Missiakas D. N-acetylglucosaminylation of serine-aspartate repeat proteins promotes Staphylococcus aureus bloodstream infection. J Biol Chem. 2014 Feb 07; 289(6):3478-86. View in: PubMed

  53. Kim HK, Emolo C, Missiakas D, Schneewind O. A monoclonal antibody that recognizes the E domain of staphylococcal protein A. Vaccine. 2014 Jan 16; 32(4):464-9. View in: PubMed

  54. Schneewind O, Missiakas D. Sec-secretion and sortase-mediated anchoring of proteins in Gram-positive bacteria. Biochim Biophys Acta. 2014 Aug; 1843(8):1687-97. View in: PubMed

  55. Thammavongsa V, Missiakas DM, Schneewind O. Staphylococcus aureus degrades neutrophil extracellular traps to promote immune cell death. Science. 2013 Nov 15; 342(6160):863-6. View in: PubMed

  56. Kopaskie KS, Ligtenberg KG, Schneewind O. Translational regulation of Yersinia enterocolitica mRNA encoding a type III secretion substrate. J Biol Chem. 2013 Dec 06; 288(49):35478-88. View in: PubMed

  57. Falugi F, Kim HK, Missiakas DM, Schneewind O. Role of protein A in the evasion of host adaptive immune responses by Staphylococcus aureus. MBio. 2013 Aug 27; 4(5):e00575-13. View in: PubMed

  58. Chen C, Krishnan V, Macon K, Manne K, Narayana SV, Schneewind O. Secreted proteases control autolysin-mediated biofilm growth of Staphylococcus aureus. J Biol Chem. 2013 Oct 11; 288(41):29440-52. View in: PubMed

  59. Thomer L, Schneewind O, Missiakas D. Multiple ligands of von Willebrand factor-binding protein (vWbp) promote Staphylococcus aureus clot formation in human plasma. J Biol Chem. 2013 Sep 27; 288(39):28283-92. View in: PubMed

  60. Chan YG, Frankel MB, Dengler V, Schneewind O, Missiakas D. Staphylococcus aureus mutants lacking the LytR-CpsA-Psr family of enzymes release cell wall teichoic acids into the extracellular medium. J Bacteriol. 2013 Oct; 195(20):4650-9. View in: PubMed

  61. Vanassche T, Peetermans M, Van Aelst LN, Peetermans WE, Verhaegen J, Missiakas DM, Schneewind O, Hoylaerts MF, Verhamme P. The role of staphylothrombin-mediated fibrin deposition in catheter-related Staphylococcus aureus infections. J Infect Dis. 2013 Jul; 208(1):92-100. View in: PubMed

  62. Missiakas DM, Schneewind O. Growth and laboratory maintenance of Staphylococcus aureus. Curr Protoc Microbiol. 2013 Feb; Chapter 9:Unit 9C.1. View in: PubMed

  63. Richter SG, Elli D, Kim HK, Hendrickx AP, Sorg JA, Schneewind O, Missiakas D. Small molecule inhibitor of lipoteichoic acid synthesis is an antibiotic for Gram-positive bacteria. Proc Natl Acad Sci U S A. 2013 Feb 26; 110(9):3531-6. View in: PubMed

  64. Oh SY, Maier H, Schroeder J, Richter GS, Elli D, Musser JM, Quenee LE, Missiakas DM, Schneewind O. Vaccine protection against Bacillus cereus-mediated respiratory anthrax-like disease in mice. Infect Immun. 2013 Mar; 81(3):1008-17. View in: PubMed

  65. Lunderberg JM, Nguyen-Mau SM, Richter GS, Wang YT, Dworkin J, Missiakas DM, Schneewind O. Bacillus anthracis acetyltransferases PatA1 and PatA2 modify the secondary cell wall polysaccharide and affect the assembly of S-layer proteins. J Bacteriol. 2013 Mar; 195(5):977-89. View in: PubMed

  66. Ligtenberg KG, Miller NC, Mitchell A, Plano GV, Schneewind O. LcrV mutants that abolish Yersinia type III injectisome function. J Bacteriol. 2013 Feb; 195(4):777-87. View in: PubMed

  67. Wang YT, Oh SY, Hendrickx AP, Lunderberg JM, Schneewind O. Bacillus cereus G9241 S-layer assembly contributes to the pathogenesis of anthrax-like disease in mice. J Bacteriol. 2013 Feb; 195(3):596-605. View in: PubMed

  68. Quenee LE, Hermanas TM, Ciletti N, Louvel H, Miller NC, Elli D, Blaylock B, Mitchell A, Schroeder J, Krausz T, Kanabrocki J, Schneewind O. Hereditary hemochromatosis restores the virulence of plague vaccine strains. J Infect Dis. 2012 Oct 01; 206(7):1050-8. View in: PubMed

  69. Kim HK, Emolo C, DeDent AC, Falugi F, Missiakas DM, Schneewind O. Protein A-specific monoclonal antibodies and prevention of Staphylococcus aureus disease in mice. Infect Immun. 2012 Oct; 80(10):3460-70. View in: PubMed

  70. McAdow M, DeDent AC, Emolo C, Cheng AG, Kreiswirth BN, Missiakas DM, Schneewind O. Coagulases as determinants of protective immune responses against Staphylococcus aureus. Infect Immun. 2012 Oct; 80(10):3389-98. View in: PubMed

  71. Rauch S, DeDent AC, Kim HK, Bubeck Wardenburg J, Missiakas DM, Schneewind O. Abscess formation and alpha-hemolysin induced toxicity in a mouse model of Staphylococcus aureus peritoneal infection. Infect Immun. 2012 Oct; 80(10):3721-32. View in: PubMed

  72. Garufi G, Hendrickx AP, Beeri K, Kern JW, Sharma A, Richter SG, Schneewind O, Missiakas D. Synthesis of lipoteichoic acids in Bacillus anthracis. J Bacteriol. 2012 Aug; 194(16):4312-21. View in: PubMed

  73. Hendrickx AP, Poor CB, Jureller JE, Budzik JM, He C, Schneewind O. Isopeptide bonds of the major pilin protein BcpA influence pilus structure and bundle formation on the surface of Bacillus cereus. Mol Microbiol. 2012 Jul; 85(1):152-63. View in: PubMed

  74. Kern VJ, Kern JW, Theriot JA, Schneewind O, Missiakas D. Surface-layer (S-layer) proteins sap and EA1 govern the binding of the S-layer-associated protein BslO at the cell septa of Bacillus anthracis. J Bacteriol. 2012 Aug; 194(15):3833-40. View in: PubMed

  75. Nguyen-Mau SM, Oh SY, Kern VJ, Missiakas DM, Schneewind O. Secretion genes as determinants of Bacillus anthracis chain length. J Bacteriol. 2012 Aug; 194(15):3841-50. View in: PubMed

  76. Houppert AS, Kwiatkowski E, Glass EM, DeBord KL, Merritt PM, Schneewind O, Marketon MM. Identification of chromosomal genes in Yersinia pestis that influence type III secretion and delivery of Yops into target cells. PLoS One. 2012; 7(3):e34039. View in: PubMed

  77. Tonry JH, McNichol BA, Ramarao N, Chertow DS, Kim KS, Stibitz S, Schneewind O, Kashanchi F, Bailey CL, Popov S, Chung MC. Bacillus anthracis protease InhA regulates BslA-mediated adhesion in human endothelial cells. Cell Microbiol. 2012 Aug; 14(8):1219-30. View in: PubMed

  78. Garufi G, Wang YT, Oh SY, Maier H, Missiakas DM, Schneewind O. Sortase-conjugation generates a capsule vaccine that protects guinea pigs against Bacillus anthracis. Vaccine. 2012 May 14; 30(23):3435-44. View in: PubMed

  79. Vanassche T, Kauskot A, Verhaegen J, Peetermans WE, van Ryn J, Schneewind O, Hoylaerts MF, Verhamme P. Fibrin formation by staphylothrombin facilitates Staphylococcus aureus-induced platelet aggregation. Thromb Haemost. 2012 Jun; 107(6):1107-21. View in: PubMed

  80. Schneewind O, Missiakas DM. Protein secretion and surface display in Gram-positive bacteria. Philos Trans R Soc Lond B Biol Sci. 2012 Apr 19; 367(1592):1123-39. View in: PubMed

  81. Frankel MB, Schneewind O. Determinants of murein hydrolase targeting to cross-wall of Staphylococcus aureus peptidoglycan. J Biol Chem. 2012 Mar 23; 287(13):10460-71. View in: PubMed

  82. Miller NC, Quenee LE, Elli D, Ciletti NA, Schneewind O. Polymorphisms in the lcrV gene of Yersinia enterocolitica and their effect on plague protective immunity. Infect Immun. 2012 Apr; 80(4):1572-82. View in: PubMed

  83. McAdow M, Missiakas DM, Schneewind O. Staphylococcus aureus secretes coagulase and von Willebrand factor binding protein to modify the coagulation cascade and establish host infections. J Innate Immun. 2012; 4(2):141-8. View in: PubMed

  84. DeDent A, Kim HK, Missiakas D, Schneewind O. Exploring Staphylococcus aureus pathways to disease for vaccine development. Semin Immunopathol. 2012 Mar; 34(2):317-33. View in: PubMed

  85. Kim HK, Thammavongsa V, Schneewind O, Missiakas D. Recurrent infections and immune evasion strategies of Staphylococcus aureus. Curr Opin Microbiol. 2012 Feb; 15(1):92-9. View in: PubMed

  86. Vanassche T, Verhaegen J, Peetermans WE, VAN Ryn J, Cheng A, Schneewind O, Hoylaerts MF, Verhamme P. Inhibition of staphylothrombin by dabigatran reduces Staphylococcus aureus virulence. J Thromb Haemost. 2011 Dec; 9(12):2436-46. View in: PubMed

  87. Thammavongsa V, Schneewind O, Missiakas DM. Enzymatic properties of Staphylococcus aureus adenosine synthase (AdsA). BMC Biochem. 2011 Oct 28; 12:56. View in: PubMed

  88. McAdow M, Kim HK, Dedent AC, Hendrickx AP, Schneewind O, Missiakas DM. Preventing Staphylococcus aureus sepsis through the inhibition of its agglutination in blood. PLoS Pathog. 2011 Oct; 7(10):e1002307. View in: PubMed

  89. Wright AM, Beres SB, Consamus EN, Long SW, Flores AR, Barrios R, Richter GS, Oh SY, Garufi G, Maier H, Drews AL, Stockbauer KE, Cernoch P, Schneewind O, Olsen RJ, Musser JM. Rapidly progressive, fatal, inhalation anthrax-like infection in a human: case report, pathogen genome sequencing, pathology, and coordinated response. Arch Pathol Lab Med. 2011 Nov; 135(11):1447-59. View in: PubMed

  90. Panizzi P, Nahrendorf M, Figueiredo JL, Panizzi J, Marinelli B, Iwamoto Y, Keliher E, Maddur AA, Waterman P, Kroh HK, Leuschner F, Aikawa E, Swirski FK, Pittet MJ, Hackeng TM, Fuentes-Prior P, Schneewind O, Bock PE, Weissleder R. In vivo detection of Staphylococcus aureus endocarditis by targeting pathogen-specific prothrombin activation. Nat Med. 2011 Aug 21; 17(9):1142-6. View in: PubMed

  91. Kobayashi SD, Malachowa N, Whitney AR, Braughton KR, Gardner DJ, Long D, Bubeck Wardenburg J, Schneewind O, Otto M, Deleo FR. Comparative analysis of USA300 virulence determinants in a rabbit model of skin and soft tissue infection. J Infect Dis. 2011 Sep 15; 204(6):937-41. View in: PubMed

  92. Frankel MB, Hendrickx AP, Missiakas DM, Schneewind O. LytN, a murein hydrolase in the cross-wall compartment of Staphylococcus aureus, is involved in proper bacterial growth and envelope assembly. J Biol Chem. 2011 Sep 16; 286(37):32593-605. View in: PubMed

  93. Quenee LE, Ciletti NA, Elli D, Hermanas TM, Schneewind O. Prevention of pneumonic plague in mice, rats, guinea pigs and non-human primates with clinical grade rV10, rV10-2 or F1-V vaccines. Vaccine. 2011 Sep 02; 29(38):6572-83. View in: PubMed

  94. Kim HK, Kim HY, Schneewind O, Missiakas D. Identifying protective antigens of Staphylococcus aureus, a pathogen that suppresses host immune responses. FASEB J. 2011 Oct; 25(10):3605-12. View in: PubMed

  95. Frank KM, Schneewind O, Shieh WJ. Investigation of a researcher's death due to septicemic plague. N Engl J Med. 2011 Jun 30; 364(26):2563-4. View in: PubMed

  96. Schneewind O, Missiakas D. Structural vaccinology to thwart antigenic variation in microbial pathogens. Proc Natl Acad Sci U S A. 2011 Jun 21; 108(25):10029-30. View in: PubMed

  97. Anderson VJ, Kern JW, McCool JW, Schneewind O, Missiakas D. The SLH-domain protein BslO is a determinant of Bacillus anthracis chain length. Mol Microbiol. 2011 Jul; 81(1):192-205. View in: PubMed

  98. Kern J, Wilton R, Zhang R, Binkowski TA, Joachimiak A, Schneewind O. Structure of surface layer homology (SLH) domains from Bacillus anthracis surface array protein. J Biol Chem. 2011 Jul 22; 286(29):26042-9. View in: PubMed

  99. Losada L, Varga JJ, Hostetler J, Radune D, Kim M, Durkin S, Schneewind O, Nierman WC. Genome sequencing and analysis of Yersina pestis KIM D27, an avirulent strain exempt from select agent regulation. PLoS One. 2011 Apr 29; 6(4):e19054. View in: PubMed

  100. Quenee LE, Ciletti N, Berube B, Krausz T, Elli D, Hermanas T, Schneewind O. Plague in Guinea pigs and its prevention by subunit vaccines. Am J Pathol. 2011 Apr; 178(4):1689-700. View in: PubMed

  101. Oh SY, Budzik JM, Garufi G, Schneewind O. Two capsular polysaccharides enable Bacillus cereus G9241 to cause anthrax-like disease. Mol Microbiol. 2011 Apr; 80(2):455-70. View in: PubMed

  102. Cheng AG, DeDent AC, Schneewind O, Missiakas D. A play in four acts: Staphylococcus aureus abscess formation. Trends Microbiol. 2011 May; 19(5):225-32. View in: PubMed

  103. Hendrickx AP, Budzik JM, Oh SY, Schneewind O. Architects at the bacterial surface - sortases and the assembly of pili with isopeptide bonds. Nat Rev Microbiol. 2011 Mar; 9(3):166-76. View in: PubMed

  104. Frankel MB, Wojcik BM, DeDent AC, Missiakas DM, Schneewind O. ABI domain-containing proteins contribute to surface protein display and cell division in Staphylococcus aureus. Mol Microbiol. 2010 Oct; 78(1):238-52. View in: PubMed

  105. Kennedy AD, Bubeck Wardenburg J, Gardner DJ, Long D, Whitney AR, Braughton KR, Schneewind O, DeLeo FR. Targeting of alpha-hemolysin by active or passive immunization decreases severity of USA300 skin infection in a mouse model. J Infect Dis. 2010 Oct 01; 202(7):1050-8. View in: PubMed

  106. Kim HK, Cheng AG, Kim HY, Missiakas DM, Schneewind O. Nontoxigenic protein A vaccine for methicillin-resistant Staphylococcus aureus infections in mice. J Exp Med. 2010 Aug 30; 207(9):1863-70. View in: PubMed

  107. Cheng AG, McAdow M, Kim HK, Bae T, Missiakas DM, Schneewind O. Contribution of coagulases towards Staphylococcus aureus disease and protective immunity. PLoS Pathog. 2010 Aug 05; 6(8):e1001036. View in: PubMed

  108. Banigan JR, Mandal K, Sawaya MR, Thammavongsa V, Hendrickx AP, Schneewind O, Yeates TO, Kent SB. Determination of the X-ray structure of the snake venom protein omwaprin by total chemical synthesis and racemic protein crystallography. Protein Sci. 2010 Oct; 19(10):1840-9. View in: PubMed

  109. Kern J, Ryan C, Faull K, Schneewind O. Bacillus anthracis surface-layer proteins assemble by binding to the secondary cell wall polysaccharide in a manner that requires csaB and tagO. J Mol Biol. 2010 Sep 03; 401(5):757-75. View in: PubMed

  110. Li C, Sun F, Cho H, Yelavarthi V, Sohn C, He C, Schneewind O, Bae T. CcpA mediates proline auxotrophy and is required for Staphylococcus aureus pathogenesis. J Bacteriol. 2010 Aug; 192(15):3883-92. View in: PubMed

  111. Kim HK, DeDent A, Cheng AG, McAdow M, Bagnoli F, Missiakas DM, Schneewind O. IsdA and IsdB antibodies protect mice against Staphylococcus aureus abscess formation and lethal challenge. Vaccine. 2010 Aug 31; 28(38):6382-92. View in: PubMed

  112. Quenee LE, Berube BJ, Segal J, Elli D, Ciletti NA, Anderson D, Schneewind O. Amino acid residues 196-225 of LcrV represent a plague protective epitope. Vaccine. 2010 Feb 17; 28(7):1870-6. View in: PubMed

  113. Blaylock B, Berube BJ, Schneewind O. YopR impacts type III needle polymerization in Yersinia species. Mol Microbiol. 2010 Jan; 75(1):221-9. View in: PubMed

  114. Kern J, Schneewind O. BslA, the S-layer adhesin of B. anthracis, is a virulence factor for anthrax pathogenesis. Mol Microbiol. 2010 Jan; 75(2):324-32. View in: PubMed

  115. Budzik JM, Poor CB, Faull KF, Whitelegge JP, He C, Schneewind O. Intramolecular amide bonds stabilize pili on the surface of bacilli. Proc Natl Acad Sci U S A. 2009 Nov 24; 106(47):19992-7. View in: PubMed

  116. Ebrahimi CM, Kern JW, Sheen TR, Ebrahimi-Fardooee MA, van Sorge NM, Schneewind O, Doran KS. Penetration of the blood-brain barrier by Bacillus anthracis requires the pXO1-encoded BslA protein. J Bacteriol. 2009 Dec; 191(23):7165-73. View in: PubMed

  117. Thammavongsa V, Kern JW, Missiakas DM, Schneewind O. Staphylococcus aureus synthesizes adenosine to escape host immune responses. J Exp Med. 2009 Oct 26; 206(11):2417-27. View in: PubMed

  118. Quenee LE, Schneewind O. Plague vaccines and the molecular basis of immunity against Yersinia pestis. Hum Vaccin. 2009 Dec; 5(12):817-23. View in: PubMed

  119. Cheng AG, Kim HK, Burts ML, Krausz T, Schneewind O, Missiakas DM. Genetic requirements for Staphylococcus aureus abscess formation and persistence in host tissues. FASEB J. 2009 Oct; 23(10):3393-404. View in: PubMed

  120. Mandal K, Pentelute BL, Tereshko V, Thammavongsa V, Schneewind O, Kossiakoff AA, Kent SB. Racemic crystallography of synthetic protein enantiomers used to determine the X-ray structure of plectasin by direct methods. Protein Sci. 2009 Jun; 18(6):1146-54. View in: PubMed

  121. Budzik JM, Oh SY, Schneewind O. Sortase D forms the covalent bond that links BcpB to the tip of Bacillus cereus pili. J Biol Chem. 2009 May 08; 284(19):12989-97. View in: PubMed

  122. Cornelius CA, Quenee LE, Elli D, Ciletti NA, Schneewind O. Yersinia pestis IS1541 transposition provides for escape from plague immunity. Infect Immun. 2009 May; 77(5):1807-16. View in: PubMed

  123. Lu D, Wörmann ME, Zhang X, Schneewind O, Gründling A, Freemont PS. Structure-based mechanism of lipoteichoic acid synthesis by Staphylococcus aureus LtaS. Proc Natl Acad Sci U S A. 2009 Feb 03; 106(5):1584-9. View in: PubMed

  124. Anderson DM, Ciletti NA, Lee-Lewis H, Elli D, Segal J, DeBord KL, Overheim KA, Tretiakova M, Brubaker RR, Schneewind O. Pneumonic plague pathogenesis and immunity in Brown Norway rats. Am J Pathol. 2009 Mar; 174(3):910-21. View in: PubMed

  125. Richter S, Anderson VJ, Garufi G, Lu L, Budzik JM, Joachimiak A, He C, Schneewind O, Missiakas D. Capsule anchoring in Bacillus anthracis occurs by a transpeptidation reaction that is inhibited by capsidin. Mol Microbiol. 2009 Jan; 71(2):404-20. View in: PubMed

  126. Blaylock B, Sorg JA, Schneewind O. Yersinia enterocolitica type III secretion of YopR requires a structure in its mRNA. Mol Microbiol. 2008 Dec; 70(5):1210-22. View in: PubMed

  127. Budzik JM, Oh SY, Schneewind O. Cell wall anchor structure of BcpA pili in Bacillus anthracis. J Biol Chem. 2008 Dec 26; 283(52):36676-86. View in: PubMed

  128. Depaolo RW, Tang F, Kim I, Han M, Levin N, Ciletti N, Lin A, Anderson D, Schneewind O, Jabri B. Toll-like receptor 6 drives differentiation of tolerogenic dendritic cells and contributes to LcrV-mediated plague pathogenesis. Cell Host Microbe. 2008 Oct 16; 4(4):350-61. View in: PubMed

  129. DeDent A, Bae T, Missiakas DM, Schneewind O. Signal peptides direct surface proteins to two distinct envelope locations of Staphylococcus aureus. EMBO J. 2008 Oct 22; 27(20):2656-68. View in: PubMed

  130. Cornelius CA, Quenee LE, Overheim KA, Koster F, Brasel TL, Elli D, Ciletti NA, Schneewind O. Immunization with recombinant V10 protects cynomolgus macaques from lethal pneumonic plague. Infect Immun. 2008 Dec; 76(12):5588-97. View in: PubMed

  131. Oh SY, Budzik JM, Schneewind O. Sortases make pili from three ingredients. Proc Natl Acad Sci U S A. 2008 Sep 16; 105(37):13703-4. View in: PubMed

  132. Bubeck Wardenburg J, Palazzolo-Ballance AM, Otto M, Schneewind O, DeLeo FR. Panton-Valentine leukocidin is not a virulence determinant in murine models of community-associated methicillin-resistant Staphylococcus aureus disease. J Infect Dis. 2008 Oct 15; 198(8):1166-70. View in: PubMed

  133. Maresso AW, Garufi G, Schneewind O. Bacillus anthracis secretes proteins that mediate heme acquisition from hemoglobin. PLoS Pathog. 2008 Aug 22; 4(8):e1000132. View in: PubMed

  134. Riordan KE, Sorg JA, Berube BJ, Schneewind O. Impassable YscP substrates and their impact on the Yersinia enterocolitica type III secretion pathway. J Bacteriol. 2008 Sep; 190(18):6204-16. View in: PubMed

  135. Budzik JM, Marraffini LA, Souda P, Whitelegge JP, Faull KF, Schneewind O. Amide bonds assemble pili on the surface of bacilli. Proc Natl Acad Sci U S A. 2008 Jul 22; 105(29):10215-20. View in: PubMed

  136. Riordan KE, Schneewind O. YscU cleavage and the assembly of Yersinia type III secretion machine complexes. Mol Microbiol. 2008 Jun; 68(6):1485-501. View in: PubMed

  137. Bae T, Glass EM, Schneewind O, Missiakas D. Generating a collection of insertion mutations in the Staphylococcus aureus genome using bursa aurealis. Methods Mol Biol. 2008; 416:103-16. View in: PubMed

  138. Kern JW, Schneewind O. BslA, a pXO1-encoded adhesin of Bacillus anthracis. Mol Microbiol. 2008 Apr; 68(2):504-15. View in: PubMed

  139. Quenee LE, Cornelius CA, Ciletti NA, Elli D, Schneewind O. Yersinia pestis caf1 variants and the limits of plague vaccine protection. Infect Immun. 2008 May; 76(5):2025-36. View in: PubMed

  140. Maresso AW, Schneewind O. Sortase as a target of anti-infective therapy. Pharmacol Rev. 2008 Mar; 60(1):128-41. View in: PubMed

  141. Bubeck Wardenburg J, Schneewind O. Vaccine protection against Staphylococcus aureus pneumonia. J Exp Med. 2008 Feb 18; 205(2):287-94. View in: PubMed

  142. Bubeck Wardenburg J, Bae T, Otto M, Deleo FR, Schneewind O. Poring over pores: alpha-hemolysin and Panton-Valentine leukocidin in Staphylococcus aureus pneumonia. Nat Med. 2007 Dec; 13(12):1405-6. View in: PubMed

  143. Fujiya M, Musch MW, Nakagawa Y, Hu S, Alverdy J, Kohgo Y, Schneewind O, Jabri B, Chang EB. The Bacillus subtilis quorum-sensing molecule CSF contributes to intestinal homeostasis via OCTN2, a host cell membrane transporter. Cell Host Microbe. 2007 Jun 14; 1(4):299-308. View in: PubMed

  144. Cornelius C, Quenee L, Anderson D, Schneewind O. Protective immunity against plague. Adv Exp Med Biol. 2007; 603:415-24. View in: PubMed

  145. Baba T, Bae T, Schneewind O, Takeuchi F, Hiramatsu K. Genome sequence of Staphylococcus aureus strain Newman and comparative analysis of staphylococcal genomes: polymorphism and evolution of two major pathogenicity islands. J Bacteriol. 2008 Jan; 190(1):300-10. View in: PubMed

  146. Budzik JM, Marraffini LA, Schneewind O. Assembly of pili on the surface of Bacillus cereus vegetative cells. Mol Microbiol. 2007 Oct; 66(2):495-510. View in: PubMed

  147. Quenee LE, Schneewind O. Ubiquitin-Yop hybrids as probes for post-translational transport by the Yersinia type III secretion pathway. Mol Microbiol. 2007 Jul; 65(2):386-400. View in: PubMed

  148. Marraffini LA, Schneewind O. Sortase C-mediated anchoring of BasI to the cell wall envelope of Bacillus anthracis. J Bacteriol. 2007 Sep; 189(17):6425-36. View in: PubMed

  149. Maresso AW, Wu R, Kern JW, Zhang R, Janik D, Missiakas DM, Duban ME, Joachimiak A, Schneewind O. Activation of inhibitors by sortase triggers irreversible modification of the active site. J Biol Chem. 2007 Aug 10; 282(32):23129-39. View in: PubMed

  150. Gründling A, Schneewind O. Synthesis of glycerol phosphate lipoteichoic acid in Staphylococcus aureus. Proc Natl Acad Sci U S A. 2007 May 15; 104(20):8478-83. View in: PubMed

  151. DeDent AC, McAdow M, Schneewind O. Distribution of protein A on the surface of Staphylococcus aureus. J Bacteriol. 2007 Jun; 189(12):4473-84. View in: PubMed

  152. Gründling A, Schneewind O. Genes required for glycolipid synthesis and lipoteichoic acid anchoring in Staphylococcus aureus. J Bacteriol. 2007 Mar; 189(6):2521-30. View in: PubMed

  153. Bubeck Wardenburg J, Patel RJ, Schneewind O. Surface proteins and exotoxins are required for the pathogenesis of Staphylococcus aureus pneumonia. Infect Immun. 2007 Feb; 75(2):1040-4. View in: PubMed

  154. Bae T, Baba T, Hiramatsu K, Schneewind O. Prophages of Staphylococcus aureus Newman and their contribution to virulence. Mol Microbiol. 2006 Nov; 62(4):1035-47. View in: PubMed

  155. Stranger-Jones YK, Bae T, Schneewind O. Vaccine assembly from surface proteins of Staphylococcus aureus. Proc Natl Acad Sci U S A. 2006 Nov 07; 103(45):16942-7. View in: PubMed

  156. Marraffini LA, Schneewind O. Targeting proteins to the cell wall of sporulating Bacillus anthracis. Mol Microbiol. 2006 Dec; 62(5):1402-17. View in: PubMed

  157. Sorg JA, Blaylock B, Schneewind O. Secretion signal recognition by YscN, the Yersinia type III secretion ATPase. Proc Natl Acad Sci U S A. 2006 Oct 31; 103(44):16490-5. View in: PubMed

  158. Torres VJ, Pishchany G, Humayun M, Schneewind O, Skaar EP. Staphylococcus aureus IsdB is a hemoglobin receptor required for heme iron utilization. J Bacteriol. 2006 Dec; 188(24):8421-9. View in: PubMed

  159. Budzik JM, Schneewind O. Pili prove pertinent to enterococcal endocarditis. J Clin Invest. 2006 Oct; 116(10):2582-4. View in: PubMed

  160. Maresso AW, Chapa TJ, Schneewind O. Surface protein IsdC and Sortase B are required for heme-iron scavenging of Bacillus anthracis. J Bacteriol. 2006 Dec; 188(23):8145-52. View in: PubMed

  161. Chen PR, Bae T, Williams WA, Duguid EM, Rice PA, Schneewind O, He C. An oxidation-sensing mechanism is used by the global regulator MgrA in Staphylococcus aureus. Nat Chem Biol. 2006 Nov; 2(11):591-5. View in: PubMed

  162. Gründling A, Missiakas DM, Schneewind O. Staphylococcus aureus mutants with increased lysostaphin resistance. J Bacteriol. 2006 Sep; 188(17):6286-97. View in: PubMed

  163. DeBord KL, Anderson DM, Marketon MM, Overheim KA, DePaolo RW, Ciletti NA, Jabri B, Schneewind O. Immunogenicity and protective immunity against bubonic plague and pneumonic plague by immunization of mice with the recombinant V10 antigen, a variant of LcrV. Infect Immun. 2006 Aug; 74(8):4910-4. View in: PubMed

  164. Maresso AW, Schneewind O. Iron acquisition and transport in Staphylococcus aureus. Biometals. 2006 Apr; 19(2):193-203. View in: PubMed

  165. Blaylock B, Riordan KE, Missiakas DM, Schneewind O. Characterization of the Yersinia enterocolitica type III secretion ATPase YscN and its regulator, YscL. J Bacteriol. 2006 May; 188(10):3525-34. View in: PubMed

  166. Gründling A, Schneewind O. Cross-linked peptidoglycan mediates lysostaphin binding to the cell wall envelope of Staphylococcus aureus. J Bacteriol. 2006 Apr; 188(7):2463-72. View in: PubMed

  167. Marraffini LA, Dedent AC, Schneewind O. Sortases and the art of anchoring proteins to the envelopes of gram-positive bacteria. Microbiol Mol Biol Rev. 2006 Mar; 70(1):192-221. View in: PubMed

  168. Skaar EP, Gaspar AH, Schneewind O. Bacillus anthracis IsdG, a heme-degrading monooxygenase. J Bacteriol. 2006 Feb; 188(3):1071-80. View in: PubMed

  169. Tao Y, Drabik KA, Waypa TS, Musch MW, Alverdy JC, Schneewind O, Chang EB, Petrof EO. Soluble factors from Lactobacillus GG activate MAPKs and induce cytoprotective heat shock proteins in intestinal epithelial cells. Am J Physiol Cell Physiol. 2006 Apr; 290(4):C1018-30. View in: PubMed

  170. Blaylock B, Schneewind O. Microbiology: loading the type III cannon. Nature. 2005 Oct 06; 437(7060):821. View in: PubMed

  171. Sorg JA, Miller NC, Marketon MM, Schneewind O. Rejection of impassable substrates by Yersinia type III secretion machines. J Bacteriol. 2005 Oct; 187(20):7090-102. View in: PubMed

  172. Sorg JA, Miller NC, Schneewind O. Substrate recognition of type III secretion machines--testing the RNA signal hypothesis. Cell Microbiol. 2005 Sep; 7(9):1217-25. View in: PubMed

  173. Marketon MM, DePaolo RW, DeBord KL, Jabri B, Schneewind O. Plague bacteria target immune cells during infection. Science. 2005 Sep 09; 309(5741):1739-41. View in: PubMed

  174. Bae T, Schneewind O. Allelic replacement in Staphylococcus aureus with inducible counter-selection. Plasmid. 2006 Jan; 55(1):58-63. View in: PubMed

  175. Overheim KA, Depaolo RW, Debord KL, Morrin EM, Anderson DM, Green NM, Brubaker RR, Jabri B, Schneewind O. LcrV plague vaccine with altered immunomodulatory properties. Infect Immun. 2005 Aug; 73(8):5152-9. View in: PubMed

  176. Gaspar AH, Marraffini LA, Glass EM, Debord KL, Ton-That H, Schneewind O. Bacillus anthracis sortase A (SrtA) anchors LPXTG motif-containing surface proteins to the cell wall envelope. J Bacteriol. 2005 Jul; 187(13):4646-55. View in: PubMed

  177. Mattner J, Debord KL, Ismail N, Goff RD, Cantu C, Zhou D, Saint-Mezard P, Wang V, Gao Y, Yin N, Hoebe K, Schneewind O, Walker D, Beutler B, Teyton L, Savage PB, Bendelac A. Exogenous and endogenous glycolipid antigens activate NKT cells during microbial infections. Nature. 2005 Mar 24; 434(7032):525-9. View in: PubMed

  178. Marraffini LA, Schneewind O. Anchor structure of staphylococcal surface proteins. V. Anchor structure of the sortase B substrate IsdC. J Biol Chem. 2005 Apr 22; 280(16):16263-71. View in: PubMed

  179. Ramamurthi KS, Schneewind O. A synonymous mutation in Yersinia enterocolitica yopE affects the function of the YopE type III secretion signal. J Bacteriol. 2005 Jan; 187(2):707-15. View in: PubMed

  180. Ton-That H, Marraffini LA, Schneewind O. Protein sorting to the cell wall envelope of Gram-positive bacteria. Biochim Biophys Acta. 2004 Nov 11; 1694(1-3):269-78. View in: PubMed

  181. Vavricka SR, Musch MW, Chang JE, Nakagawa Y, Phanvijhitsiri K, Waypa TS, Merlin D, Schneewind O, Chang EB. hPepT1 transports muramyl dipeptide, activating NF-kappaB and stimulating IL-8 secretion in human colonic Caco2/bbe cells. Gastroenterology. 2004 Nov; 127(5):1401-9. View in: PubMed

  182. Wu R, Skaar EP, Zhang R, Joachimiak G, Gornicki P, Schneewind O, Joachimiak A. Staphylococcus aureus IsdG and IsdI, heme-degrading enzymes with structural similarity to monooxygenases. J Biol Chem. 2005 Jan 28; 280(4):2840-6. View in: PubMed

  183. Cambronne ED, Schneewind O. Bacterial invasins: molecular systems dedicated to the invasion of host tissues. Contrib Microbiol. 2005; 12:181-209. View in: PubMed

  184. Skaar EP, Humayun M, Bae T, DeBord KL, Schneewind O. Iron-source preference of Staphylococcus aureus infections. Science. 2004 Sep 10; 305(5690):1626-8. View in: PubMed

  185. Goss JW, Sorg JA, Ramamurthi KS, Ton-That H, Schneewind O. The secretion signal of YopN, a regulatory protein of the Yersinia enterocolitica type III secretion pathway. J Bacteriol. 2004 Sep; 186(18):6320-4. View in: PubMed

  186. Bae T, Banger AK, Wallace A, Glass EM, Aslund F, Schneewind O, Missiakas DM. Staphylococcus aureus virulence genes identified by bursa aurealis mutagenesis and nematode killing. Proc Natl Acad Sci U S A. 2004 Aug 17; 101(33):12312-7. View in: PubMed

  187. Marraffini LA, Ton-That H, Zong Y, Narayana SV, Schneewind O. Anchoring of surface proteins to the cell wall of Staphylococcus aureus. A conserved arginine residue is required for efficient catalysis of sortase A. J Biol Chem. 2004 Sep 03; 279(36):37763-70. View in: PubMed

  188. Zhang R, Wu R, Joachimiak G, Mazmanian SK, Missiakas DM, Gornicki P, Schneewind O, Joachimiak A. Structures of sortase B from Staphylococcus aureus and Bacillus anthracis reveal catalytic amino acid triad in the active site. Structure. 2004 Jul; 12(7):1147-56. View in: PubMed

  189. Ton-That H, Marraffini LA, Schneewind O. Sortases and pilin elements involved in pilus assembly of Corynebacterium diphtheriae. Mol Microbiol. 2004 Jul; 53(1):251-61. View in: PubMed

  190. Ton-That H, Schneewind O. Assembly of pili in Gram-positive bacteria. Trends Microbiol. 2004 May; 12(5):228-34. View in: PubMed

  191. Zong Y, Bice TW, Ton-That H, Schneewind O, Narayana SV. Crystal structures of Staphylococcus aureus sortase A and its substrate complex. J Biol Chem. 2004 Jul 23; 279(30):31383-9. View in: PubMed

  192. Skaar EP, Schneewind O. Iron-regulated surface determinants (Isd) of Staphylococcus aureus: stealing iron from heme. Microbes Infect. 2004 Apr; 6(4):390-7. View in: PubMed

  193. Weiss WJ, Lenoy E, Murphy T, Tardio L, Burgio P, Projan SJ, Schneewind O, Alksne L. Effect of srtA and srtB gene expression on the virulence of Staphylococcus aureus in animal models of infection. J Antimicrob Chemother. 2004 Mar; 53(3):480-6. View in: PubMed

  194. Cambronne ED, Sorg JA, Schneewind O. Binding of SycH chaperone to YscM1 and YscM2 activates effector yop expression in Yersinia enterocolitica. J Bacteriol. 2004 Feb; 186(3):829-41. View in: PubMed

  195. Zong Y, Mazmanian SK, Schneewind O, Narayana SV. The structure of sortase B, a cysteine transpeptidase that tethers surface protein to the Staphylococcus aureus cell wall. Structure. 2004 Jan; 12(1):105-12. View in: PubMed

  196. Ton-That H, Schneewind O. Assembly of pili on the surface of Corynebacterium diphtheriae. Mol Microbiol. 2003 Nov; 50(4):1429-38. View in: PubMed

  197. Ramamurthi KS, Schneewind O. Yersinia yopQ mRNA encodes a bipartite type III secretion signal in the first 15 codons. Mol Microbiol. 2003 Nov; 50(4):1189-98. View in: PubMed

  198. Ramamurthi KS, Schneewind O. Substrate recognition by the Yersinia type III protein secretion machinery. Mol Microbiol. 2003 Nov; 50(4):1095-102. View in: PubMed

  199. Skaar EP, Gaspar AH, Schneewind O. IsdG and IsdI, heme-degrading enzymes in the cytoplasm of Staphylococcus aureus. J Biol Chem. 2004 Jan 02; 279(1):436-43. View in: PubMed

  200. Jonsson IM, Mazmanian SK, Schneewind O, Bremell T, Tarkowski A. The role of Staphylococcus aureus sortase A and sortase B in murine arthritis. Microbes Infect. 2003 Jul; 5(9):775-80. View in: PubMed

  201. DeBord KL, Galanopoulos NS, Schneewind O. The ttsA gene is required for low-calcium-induced type III secretion of Yop proteins and virulence of Yersinia enterocolitica W22703. J Bacteriol. 2003 Jun; 185(12):3499-507. View in: PubMed

  202. Bae T, Schneewind O. The YSIRK-G/S motif of staphylococcal protein A and its role in efficiency of signal peptide processing. J Bacteriol. 2003 May; 185(9):2910-9. View in: PubMed

  203. Mazmanian SK, Skaar EP, Gaspar AH, Humayun M, Gornicki P, Jelenska J, Joachmiak A, Missiakas DM, Schneewind O. Passage of heme-iron across the envelope of Staphylococcus aureus. Science. 2003 Feb 07; 299(5608):906-9. View in: PubMed

  204. Cambronne ED, Schneewind O. Yersinia enterocolitica type III secretion: yscM1 and yscM2 regulate yop gene expression by a posttranscriptional mechanism that targets the 5' untranslated region of yop mRNA. J Bacteriol. 2002 Nov; 184(21):5880-93. View in: PubMed

  205. Ramamurthi KS, Schneewind O. Type iii protein secretion in yersinia species. Annu Rev Cell Dev Biol. 2002; 18:107-33. View in: PubMed

  206. Lee VT, Schneewind O. Yop fusions to tightly folded protein domains and their effects on Yersinia enterocolitica type III secretion. J Bacteriol. 2002 Jul; 184(13):3740-5. View in: PubMed

  207. Ramamurthi KS, Schneewind O. Yersinia enterocolitica type III secretion: mutational analysis of the yopQ secretion signal. J Bacteriol. 2002 Jun; 184(12):3321-8. View in: PubMed

  208. Jonsson IM, Mazmanian SK, Schneewind O, Verdrengh M, Bremell T, Tarkowski A. On the role of Staphylococcus aureus sortase and sortase-catalyzed surface protein anchoring in murine septic arthritis. J Infect Dis. 2002 May 15; 185(10):1417-24. View in: PubMed

  209. Bierne H, Mazmanian SK, Trost M, Pucciarelli MG, Liu G, Dehoux P, Jänsch L, Garcia-del Portillo F, Schneewind O, Cossart P. Inactivation of the srtA gene in Listeria monocytogenes inhibits anchoring of surface proteins and affects virulence. Mol Microbiol. 2002 Feb; 43(4):869-81. View in: PubMed

  210. Perry AM, Ton-That H, Mazmanian SK, Schneewind O. Anchoring of surface proteins to the cell wall of Staphylococcus aureus. III. Lipid II is an in vivo peptidoglycan substrate for sortase-catalyzed surface protein anchoring. J Biol Chem. 2002 May 03; 277(18):16241-8. View in: PubMed

  211. Anderson DM, Ramamurthi KS, Tam C, Schneewind O. YopD and LcrH regulate expression of Yersinia enterocolitica YopQ by a posttranscriptional mechanism and bind to yopQ RNA. J Bacteriol. 2002 Mar; 184(5):1287-95. View in: PubMed

  212. Mazmanian SK, Ton-That H, Su K, Schneewind O. An iron-regulated sortase anchors a class of surface protein during Staphylococcus aureus pathogenesis. Proc Natl Acad Sci U S A. 2002 Feb 19; 99(4):2293-8. View in: PubMed

  213. Ton-That H, Mazmanian SK, Alksne L, Schneewind O. Anchoring of surface proteins to the cell wall of Staphylococcus aureus. Cysteine 184 and histidine 120 of sortase form a thiolate-imidazolium ion pair for catalysis. J Biol Chem. 2002 Mar 01; 277(9):7447-52. View in: PubMed

  214. Cheng LW, Kay O, Schneewind O. Regulated secretion of YopN by the type III machinery of Yersinia enterocolitica. J Bacteriol. 2001 Sep; 183(18):5293-301. View in: PubMed

  215. Lee VT, Mazmanian SK, Schneewind O. A program of Yersinia enterocolitica type III secretion reactions is activated by specific signals. J Bacteriol. 2001 Sep; 183(17):4970-8. View in: PubMed

  216. Lee VT, Schneewind O. Protein secretion and the pathogenesis of bacterial infections. Genes Dev. 2001 Jul 15; 15(14):1725-52. View in: PubMed

  217. DeBord KL, Lee VT, Schneewind O. Roles of LcrG and LcrV during type III targeting of effector Yops by Yersinia enterocolitica. J Bacteriol. 2001 Aug; 183(15):4588-98. View in: PubMed

  218. Mazmanian SK, Ton-That H, Schneewind O. Sortase-catalysed anchoring of surface proteins to the cell wall of Staphylococcus aureus. Mol Microbiol. 2001 Jun; 40(5):1049-57. View in: PubMed

  219. Ilangovan U, Ton-That H, Iwahara J, Schneewind O, Clubb RT. Structure of sortase, the transpeptidase that anchors proteins to the cell wall of Staphylococcus aureus. Proc Natl Acad Sci U S A. 2001 May 22; 98(11):6056-61. View in: PubMed

  220. Ilangovan U, Iwahara J, Ton-That H, Schneewind O, Clubb RT. Assignment of the 1H, 13C and 15N signals of Sortase. J Biomol NMR. 2001 Apr; 19(4):379-80. View in: PubMed

  221. Cambronne ED, Cheng LW, Schneewind O. LcrQ/YscM1, regulators of the Yersinia yop virulon, are injected into host cells by a chaperone-dependent mechanism. Mol Microbiol. 2000 Jul; 37(2):263-73. View in: PubMed

  222. Lee VT, Tam C, Schneewind O. LcrV, a substrate for Yersinia enterocolitica type III secretion, is required for toxin targeting into the cytosol of HeLa cells. J Biol Chem. 2000 Nov 24; 275(47):36869-75. View in: PubMed

  223. Collmer A, Badel JL, Charkowski AO, Deng WL, Fouts DE, Ramos AR, Rehm AH, Anderson DM, Schneewind O, van Dijk K, Alfano JR. Pseudomonas syringae Hrp type III secretion system and effector proteins. Proc Natl Acad Sci U S A. 2000 Aug 01; 97(16):8770-7. View in: PubMed

  224. Cheng LW, Schneewind O. Yersinia enterocolitica TyeA, an intracellular regulator of the type III machinery, is required for specific targeting of YopE, YopH, YopM, and YopN into the cytosol of eukaryotic cells. J Bacteriol. 2000 Jun; 182(11):3183-90. View in: PubMed

  225. Mazmanian SK, Liu G, Jensen ER, Lenoy E, Schneewind O. Staphylococcus aureus sortase mutants defective in the display of surface proteins and in the pathogenesis of animal infections. Proc Natl Acad Sci U S A. 2000 May 09; 97(10):5510-5. View in: PubMed

  226. Cheng LW, Schneewind O. Type III machines of Gram-negative bacteria: delivering the goods. Trends Microbiol. 2000 May; 8(5):214-20. View in: PubMed

  227. Dhar G, Faull KF, Schneewind O. Anchor structure of cell wall surface proteins in Listeria monocytogenes. Biochemistry. 2000 Apr 04; 39(13):3725-33. View in: PubMed

  228. Ton-That H, Mazmanian SK, Faull KF, Schneewind O. Anchoring of surface proteins to the cell wall of Staphylococcus aureus. Sortase catalyzed in vitro transpeptidation reaction using LPXTG peptide and NH(2)-Gly(3) substrates. J Biol Chem. 2000 Mar 31; 275(13):9876-81. View in: PubMed

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  233. Cheng LW, Schneewind O. Yersinia enterocolitica type III secretion. On the role of SycE in targeting YopE into HeLa cells. J Biol Chem. 1999 Jul 30; 274(31):22102-8. View in: PubMed

  234. Lee VT, Schneewind O. Type III secretion machines and the pathogenesis of enteric infections caused by Yersinia and Salmonella spp. Immunol Rev. 1999 Apr; 168:241-55. View in: PubMed

  235. Navarre WW, Ton-That H, Faull KF, Schneewind O. Multiple enzymatic activities of the murein hydrolase from staphylococcal phage phi11. Identification of a D-alanyl-glycine endopeptidase activity. J Biol Chem. 1999 May 28; 274(22):15847-56. View in: PubMed

  236. Lee VT, Schneewind O. Type III machines of pathogenic yersiniae secrete virulence factors into the extracellular milieu. Mol Microbiol. 1999 Mar; 31(6):1619-29. View in: PubMed

  237. Anderson DM, Schneewind O. Yersinia enterocolitica type III secretion: an mRNA signal that couples translation and secretion of YopQ. Mol Microbiol. 1999 Feb; 31(4):1139-48. View in: PubMed

  238. Navarre WW, Schneewind O. Surface proteins of gram-positive bacteria and mechanisms of their targeting to the cell wall envelope. Microbiol Mol Biol Rev. 1999 Mar; 63(1):174-229. View in: PubMed

  239. Anderson DM, Schneewind O. Type III machines of Gram-negative pathogens: injecting virulence factors into host cells and more. Curr Opin Microbiol. 1999 Feb; 2(1):18-24. View in: PubMed

  240. Ton-That H, Labischinski H, Berger-Bächi B, Schneewind O. Anchor structure of staphylococcal surface proteins. III. Role of the FemA, FemB, and FemX factors in anchoring surface proteins to the bacterial cell wall. J Biol Chem. 1998 Oct 30; 273(44):29143-9. View in: PubMed

  241. Navarre WW, Ton-That H, Faull KF, Schneewind O. Anchor structure of staphylococcal surface proteins. II. Cooh-terminal structure of muramidase and amidase-solubilized surface protein. J Biol Chem. 1998 Oct 30; 273(44):29135-42. View in: PubMed

  242. Baba T, Schneewind O. Targeting of muralytic enzymes to the cell division site of Gram-positive bacteria: repeat domains direct autolysin to the equatorial surface ring of Staphylococcus aureus. EMBO J. 1998 Aug 17; 17(16):4639-46. View in: PubMed

  243. Lee VT, Anderson DM, Schneewind O. Targeting of Yersinia Yop proteins into the cytosol of HeLa cells: one-step translocation of YopE across bacterial and eukaryotic membranes is dependent on SycE chaperone. Mol Microbiol. 1998 May; 28(3):593-601. View in: PubMed

  244. Baba T, Schneewind O. Instruments of microbial warfare: bacteriocin synthesis, toxicity and immunity. Trends Microbiol. 1998 Feb; 6(2):66-71. View in: PubMed

  245. Anderson DM, Schneewind O. A mRNA signal for the type III secretion of Yop proteins by Yersinia enterocolitica. Science. 1997 Nov 07; 278(5340):1140-3. View in: PubMed

  246. Ton-That H, Faull KF, Schneewind O. Anchor structure of staphylococcal surface proteins. A branched peptide that links the carboxyl terminus of proteins to the cell wall. J Biol Chem. 1997 Aug 29; 272(35):22285-92. View in: PubMed

  247. Cheng LW, Anderson DM, Schneewind O. Two independent type III secretion mechanisms for YopE in Yersinia enterocolitica. Mol Microbiol. 1997 May; 24(4):757-65. View in: PubMed

  248. Baba T, Schneewind O. Target cell specificity of a bacteriocin molecule: a C-terminal signal directs lysostaphin to the cell wall of Staphylococcus aureus. EMBO J. 1996 Sep 16; 15(18):4789-97. View in: PubMed

  249. Navarre WW, Daefler S, Schneewind O. Cell wall sorting of lipoproteins in Staphylococcus aureus. J Bacteriol. 1996 Jan; 178(2):441-6. View in: PubMed

  250. Martin de Llano JJ, Schneewind O, Stetler G, Manning JM. Recombinant human sickle hemoglobin expressed in yeast. Proc Natl Acad Sci U S A. 1993 Feb 01; 90(3):918-22. View in: PubMed

  251. Schneewind O, Mihaylova-Petkov D, Model P. Cell wall sorting signals in surface proteins of gram-positive bacteria. EMBO J. 1993 Dec; 12(12):4803-11. View in: PubMed

  252. Martin de Llano JJ, Schneewind O, Stetler GL, Manning JM. Purification and characterization of recombinant human sickle hemoglobin expressed in yeast. Methods Enzymol. 1994; 231:390-403. View in: PubMed

  253. Navarre WW, Schneewind O. Proteolytic cleavage and cell wall anchoring at the LPXTG motif of surface proteins in gram-positive bacteria. Mol Microbiol. 1994 Oct; 14(1):115-21. View in: PubMed

  254. Schneewind O, Fowler A, Faull KF. Structure of the cell wall anchor of surface proteins in Staphylococcus aureus. Science. 1995 Apr 07; 268(5207):103-6. View in: PubMed

  255. Schneewind O, Friedrich K, Lütticken R. Cloning and expression of the CAMP factor of group B streptococci in Escherichia coli. Infect Immun. 1988 Aug; 56(8):2174-9. View in: PubMed

  256. Fischetti VA, Pancholi V, Schneewind O. Conservation of a hexapeptide sequence in the anchor region of surface proteins from gram-positive cocci. Mol Microbiol. 1990 Sep; 4(9):1603-5. View in: PubMed

  257. Schneewind O, Jones KF, Fischetti VA. Sequence and structural characteristics of the trypsin-resistant T6 surface protein of group A streptococci. J Bacteriol. 1990 Jun; 172(6):3310-7. View in: PubMed

  258. Hruby DE, Schneewind O, Wilson EM, Fischetti VA. Assembly and analysis of a functional vaccinia virus "amplicon" containing the C-repeat region from the M protein of Streptococcus pyogenes. Proc Natl Acad Sci U S A. 1991 Apr 15; 88(8):3190-4. View in: PubMed

  259. Jones WM, Scaloni A, Bossa F, Popowicz AM, Schneewind O, Manning JM. Genetic relationship between acylpeptide hydrolase and acylase, two hydrolytic enzymes with similar binding but different catalytic specificities. Proc Natl Acad Sci U S A. 1991 Mar 15; 88(6):2194-8. View in: PubMed

  260. Hall WW, Liu CR, Schneewind O, Takahashi H, Kaplan MH, Röupe G, Vahlne A. Deleted HTLV-I provirus in blood and cutaneous lesions of patients with mycosis fungoides. Science. 1991 Jul 19; 253(5017):317-20. View in: PubMed

  261. Jones KF, Schneewind O, Koomey JM, Fischetti VA. Genetic diversity among the T-protein genes of group A streptococci. Mol Microbiol. 1991 Dec; 5(12):2947-52. View in: PubMed

  262. Fischetti VA, Bessen DE, Schneewind O, Hruby DE. Protection against streptococcal pharyngeal colonization with vaccines composed of M protein conserved regions. Adv Exp Med Biol. 1991; 303:159-67. View in: PubMed

  263. Scaloni A, Jones WM, Barra D, Pospischil M, Sassa S, Popowicz A, Manning LR, Schneewind O, Manning JM. Acylpeptide hydrolase: inhibitors and some active site residues of the human enzyme. J Biol Chem. 1992 Feb 25; 267(6):3811-8. View in: PubMed

  264. Schneewind O, Model P, Fischetti VA. Sorting of protein A to the staphylococcal cell wall. Cell. 1992 Jul 24; 70(2):267-81. View in: PubMed

  265. Scaloni A, Jones W, Pospischil M, Sassa S, Schneewind O, Popowicz AM, Bossa F, Graziano SL, Manning JM. Deficiency of acylpeptide hydrolase in small-cell lung carcinoma cell lines. J Lab Clin Med. 1992 Oct; 120(4):546-52. View in: PubMed