Biological systems are thought to be exceedingly 'complex'--comprised of many parts and sets of unintuitive interactions between parts conferring system function. My lab is interested in elucidating principles of structure, function, and adaptability relationships with the ultimate goals of (i) characterizing 'personalized' variation in biological systems with high-fidelity, (ii) creating tools to genetically engineer variation in a rational way, and (iii) engineering natural-like, adaptive systems de novo. We use a blend of theory, computation, and experiment applied to a range of model systems spanning neural networks to electronic health record data to complex ecosystems inhabiting humans in addressing these concepts.
Washington University in St. Louis
St. Louis
- Clinical Pathology
2020
University of Texas at Southwestern
Dallas
M.D. - Medicine
2017
University of Texas at Southwestern
Dallas
Ph.D. - Molecular Biophysics
2017
University of Chicago
Chicago
B.A. - Physics
2008
University of Chicago
Chicago
B.S. - Chemistry (Honors)
2008
Pan-tumor spatial transcriptomics reveals conserved properties of tumor organization.
Pan-tumor spatial transcriptomics reveals conserved properties of tumor organization. Cell Rep Med. 2026 Sep 15; 7(9):103013.
PMID: 42664957
Post-COVID impairment of T cell responses to community-acquired pathogens can be modified by activating cellular metabolism.
Post-COVID impairment of T cell responses to community-acquired pathogens can be modified by activating cellular metabolism. PLoS Pathog. 2026 07; 22(7):e1013860.
PMID: 42531297
Distinct trajectories of urbanization shape the human gut microbiome across South Asia.
Distinct trajectories of urbanization shape the human gut microbiome across South Asia. Gut Microbes. 2026 Dec 31; 18(1):2700042.
PMID: 42444491
Physiological architecture and evolutionary origins of cellular adaptability.
Physiological architecture and evolutionary origins of cellular adaptability. bioRxiv. 2026 Apr 11.
PMID: 41993285
Distinct trajectories of urbanization shape the human gut microbiome across South Asia.
Distinct trajectories of urbanization shape the human gut microbiome across South Asia. bioRxiv. 2026 Jan 23.
PMID: 41648281
Post-COVID impairment of memory T cell responses to community-acquired pathogens can be rectified by activating cellular metabolism.
Post-COVID impairment of memory T cell responses to community-acquired pathogens can be rectified by activating cellular metabolism. bioRxiv. 2026 Jan 02.
PMID: 41509309
Statistical design of a synthetic microbiome that suppresses diverse gut pathogens.
Statistical design of a synthetic microbiome that suppresses diverse gut pathogens. bioRxiv. 2025 Dec 31.
PMID: 41502951
ROSIE: AI generation of multiplex immunofluorescence staining from histopathology images.
ROSIE: AI generation of multiplex immunofluorescence staining from histopathology images. Nat Commun. 2025 Aug 16; 16(1):7633.
PMID: 40819165
Subspecies phylogeny in the human gut revealed by co-evolutionary constraints across the bacterial kingdom.
Subspecies phylogeny in the human gut revealed by co-evolutionary constraints across the bacterial kingdom. Cell Syst. 2025 02 19; 16(2):101167.
PMID: 39826551
ROSIE: AI generation of multiplex immunofluorescence staining from histopathology images.
ROSIE: AI generation of multiplex immunofluorescence staining from histopathology images. bioRxiv. 2024 Nov 18.
PMID: 39605711