Alexander V. Chervonsky

Biosciences Graduate Program Association
Publications
  1. Dybala MP, Kuznetsov A, Motobu M, Hendren-Santiago BK, Philipson LH, Chervonsky AV, Hara M. Integrated Pancreatic Blood Flow: Bi-Directional Microcirculation Between Endocrine and Exocrine Pancreas. Diabetes. 2020 Mar 20. View in: PubMed

  2. Wan X, Vomund AN, Peterson OJ, Chervonsky AV, Lichti CF, Unanue ER. The MHC-II peptidome of pancreatic islets identifies key features of autoimmune peptides. Nat Immunol. 2020 Apr; 21(4):455-463. View in: PubMed

  3. Jain A, Irizarry-Caro RA, McDaniel MM, Chawla AS, Carroll KR, Overcast GR, Philip NH, Oberst A, Chervonsky AV, Katz JD, Pasare C. T cells instruct myeloid cells to produce inflammasome-independent IL-1ß and cause autoimmunity. Nat Immunol. 2020 Jan; 21(1):65-74. View in: PubMed

  4. Khan AA, Yurkovetskiy L, O'Grady K, Pickard JM, de Pooter R, Antonopoulos DA, Golovkina T, Chervonsky A. Polymorphic Immune Mechanisms Regulate Commensal Repertoire. Cell Rep. 2019 Oct 15; 29(3):541-550.e4. View in: PubMed

  5. Kane M, Deiss F, Chervonsky A, Golovkina TV. A Single Locus Controls Interferon Gamma-Independent Antiretroviral Neutralizing Antibody Responses. J Virol. 2018 08 15; 92(16). View in: PubMed

  6. Denzin LK, Khan AA, Virdis F, Wilks J, Kane M, Beilinson HA, Dikiy S, Case LK, Roopenian D, Witkowski M, Chervonsky AV, Golovkina TV. Neutralizing Antibody Responses to Viral Infections Are Linked to the Non-classical MHC Class II Gene H2-Ob. Immunity. 2017 08 15; 47(2):310-322.e7. View in: PubMed

  7. Chervonsky AV. Just a Spoonful of Sugar Helps the Tolerance Go Up. Cell. 2017 06 15; 169(7):1170-1172. View in: PubMed

  8. Yoon J, Leyva-Castillo JM, Wang G, Galand C, Oyoshi MK, Kumar L, Hoff S, He R, Chervonsky A, Oppenheim JJ, Kuchroo VK, van den Brink MR, Malefyt Rde W, Tessier PA, Fuhlbrigge R, Rosenstiel P, Terhorst C, Murphy G, Geha RS. IL-23 induced in keratinocytes by endogenous TLR4 ligands polarizes dendritic cells to drive IL-22 responses to skin immunization. J Exp Med. 2016 09 19; 213(10):2147-66. View in: PubMed

  9. Wilks J, Lien E, Jacobson AN, Fischbach MA, Qureshi N, Chervonsky AV, Golovkina TV. Mammalian Lipopolysaccharide Receptors Incorporated into the Retroviral Envelope Augment Virus Transmission. Cell Host Microbe. 2015 Oct 14; 18(4):456-62. View in: PubMed

  10. Burrows MP, Volchkov P, Kobayashi KS, Chervonsky AV. Microbiota regulates type 1 diabetes through Toll-like receptors. Proc Natl Acad Sci U S A. 2015 Aug 11; 112(32):9973-7. View in: PubMed

  11. Pickard JM, Chervonsky AV. Intestinal fucose as a mediator of host-microbe symbiosis. J Immunol. 2015 Jun 15; 194(12):5588-93. View in: PubMed

  12. Yurkovetskiy LA, Pickard JM, Chervonsky AV. Microbiota and autoimmunity: exploring new avenues. Cell Host Microbe. 2015 May 13; 17(5):548-52. View in: PubMed

  13. Pickard JM, Maurice CF, Kinnebrew MA, Abt MC, Schenten D, Golovkina TV, Bogatyrev SR, Ismagilov RF, Pamer EG, Turnbaugh PJ, Chervonsky AV. Rapid fucosylation of intestinal epithelium sustains host-commensal symbiosis in sickness. Nature. 2014 Oct 30; 514(7524):638-41. View in: PubMed

  14. Rivas FV, Chervonsky AV, Medzhitov R. ART and immunology. Trends Immunol. 2014 Oct; 35(10):451. View in: PubMed

  15. Varanasi V, Khan AA, Chervonsky AV. Loss of the death receptor CD95 (Fas) expression by dendritic cells protects from a chronic viral infection. Proc Natl Acad Sci U S A. 2014 Jun 10; 111(23):8559-64. View in: PubMed

  16. Wilks J, Beilinson H, Theriault B, Chervonsky A, Golovkina T. Antibody-mediated immune control of a retrovirus does not require the microbiota. J Virol. 2014 Jun; 88(11):6524-7. View in: PubMed

  17. Wueest S, Mueller R, Blüher M, Item F, Chin AS, Wiedemann MS, Takizawa H, Kovtonyuk L, Chervonsky AV, Schoenle EJ, Manz MG, Konrad D. Fas (CD95) expression in myeloid cells promotes obesity-induced muscle insulin resistance. EMBO Mol Med. 2014 01; 6(1):43-56. View in: PubMed

  18. Yurkovetskiy L, Burrows M, Khan AA, Graham L, Volchkov P, Becker L, Antonopoulos D, Umesaki Y, Chervonsky AV. Gender bias in autoimmunity is influenced by microbiota. Immunity. 2013 Aug 22; 39(2):400-12. View in: PubMed

  19. Chervonsky AV. Microbiota and autoimmunity. Cold Spring Harb Perspect Biol. 2013 Mar 01; 5(3):a007294. View in: PubMed

  20. Atkinson MA, Chervonsky A. Does the gut microbiota have a role in type 1 diabetes? Early evidence from humans and animal models of the disease. Diabetologia. 2012 Nov; 55(11):2868-77. View in: PubMed

  21. Varanasi V, Avanesyan L, Schumann DM, Chervonsky AV. Cytotoxic mechanisms employed by mouse T cells to destroy pancreatic ß-cells. Diabetes. 2012 Nov; 61(11):2862-70. View in: PubMed

  22. Chervonsky AV. Intestinal commensals: influence on immune system and tolerance to pathogens. Curr Opin Immunol. 2012 Jun; 24(3):255-60. View in: PubMed

  23. Chervonsky AV. Solving the plot: early events are the key to diabetes intervention. Nat Immunol. 2012 Mar 19; 13(4):311-2. View in: PubMed

  24. Chervonsky AV. Microbial influences on immune function and more. Immunol Rev. 2012 Jan; 245(1):7-12. View in: PubMed

  25. Allison JP, Benoist C, Chervonsky AV. Nobels: Toll pioneers deserve recognition. Nature. 2011 Nov 09; 479(7372):178. View in: PubMed

  26. Kane M, Case LK, Kopaskie K, Kozlova A, MacDearmid C, Chervonsky AV, Golovkina TV. Successful transmission of a retrovirus depends on the commensal microbiota. Science. 2011 Oct 14; 334(6053):245-9. View in: PubMed

  27. Rudensky AY, Chervonsky AV. A narrow circle of mutual friends. Immunity. 2011 May 27; 34(5):697-9. View in: PubMed

  28. Wang Y, Devkota S, Musch MW, Jabri B, Nagler C, Antonopoulos DA, Chervonsky A, Chang EB. Regional mucosa-associated microbiota determine physiological expression of TLR2 and TLR4 in murine colon. PLoS One. 2010 Oct 22; 5(10):e13607. View in: PubMed

  29. Chinen T, Volchkov PY, Chervonsky AV, Rudensky AY. A critical role for regulatory T cell-mediated control of inflammation in the absence of commensal microbiota. J Exp Med. 2010 Oct 25; 207(11):2323-30. View in: PubMed

  30. Scott GS, Fishman S, Khai Siew L, Margalit A, Chapman S, Chervonsky AV, Wen L, Gross G, Wong FS. Immunotargeting of insulin reactive CD8 T cells to prevent diabetes. J Autoimmun. 2010 Dec; 35(4):390-7. View in: PubMed

  31. Pickard JM, Chervonsky AV. Sampling of the intestinal microbiota by epithelial M cells. Curr Gastroenterol Rep. 2010 Oct; 12(5):331-9. View in: PubMed

  32. Lee HK, Mattei LM, Steinberg BE, Alberts P, Lee YH, Chervonsky A, Mizushima N, Grinstein S, Iwasaki A. In vivo requirement for Atg5 in antigen presentation by dendritic cells. Immunity. 2010 Feb 26; 32(2):227-39. View in: PubMed

  33. Krebs LT, Starling C, Chervonsky AV, Gridley T. Notch1 activation in mice causes arteriovenous malformations phenocopied by ephrinB2 and EphB4 mutants. Genesis. 2010 Mar; 48(3):146-50. View in: PubMed

  34. Chervonsky AV. Influence of microbial environment on autoimmunity. Nat Immunol. 2010 Jan; 11(1):28-35. View in: PubMed

  35. Wueest S, Rapold RA, Schumann DM, Rytka JM, Schildknecht A, Nov O, Chervonsky AV, Rudich A, Schoenle EJ, Donath MY, Konrad D. Deletion of Fas in adipocytes relieves adipose tissue inflammation and hepatic manifestations of obesity in mice. J Clin Invest. 2010 Jan; 120(1):191-202. View in: PubMed

  36. Chervonsky A. Innate receptors and microbes in induction of autoimmunity. Curr Opin Immunol. 2009 Dec; 21(6):641-7. View in: PubMed

  37. Kamanaka M, Rainbow D, Schuster-Gossler K, Eynon EE, Chervonsky AV, Wicker LS, Flavell RA. Amino acid polymorphisms altering the glycosylation of IL-2 do not protect from type 1 diabetes in the NOD mouse. Proc Natl Acad Sci U S A. 2009 Jul 07; 106(27):11236-40. View in: PubMed

  38. Wen L, Ley RE, Volchkov PY, Stranges PB, Avanesyan L, Stonebraker AC, Hu C, Wong FS, Szot GL, Bluestone JA, Gordon JI, Chervonsky AV. Innate immunity and intestinal microbiota in the development of Type 1 diabetes. Nature. 2008 Oct 23; 455(7216):1109-13. View in: PubMed

  39. Leiter EH, Reifsnyder P, Driver J, Kamdar S, Choisy-Rossi C, Serreze DV, Hara M, Chervonsky A. Unexpected functional consequences of xenogeneic transgene expression in beta-cells of NOD mice. Diabetes Obes Metab. 2007 Nov; 9 Suppl 2:14-22. View in: PubMed

  40. Stranges PB, Watson J, Cooper CJ, Choisy-Rossi CM, Stonebraker AC, Beighton RA, Hartig H, Sundberg JP, Servick S, Kaufmann G, Fink PJ, Chervonsky AV. Elimination of antigen-presenting cells and autoreactive T cells by Fas contributes to prevention of autoimmunity. Immunity. 2007 May; 26(5):629-41. View in: PubMed

  41. Schumann DM, Maedler K, Franklin I, Konrad D, Størling J, Böni-Schnetzler M, Gjinovci A, Kurrer MO, Gauthier BR, Bosco D, Andres A, Berney T, Greter M, Becher B, Chervonsky AV, Halban PA, Mandrup-Poulsen T, Wollheim CB, Donath MY. The Fas pathway is involved in pancreatic beta cell secretory function. Proc Natl Acad Sci U S A. 2007 Feb 20; 104(8):2861-6. View in: PubMed

  42. Lee Y, Chin RK, Christiansen P, Sun Y, Tumanov AV, Wang J, Chervonsky AV, Fu YX. Recruitment and activation of naive T cells in the islets by lymphotoxin beta receptor-dependent tertiary lymphoid structure. Immunity. 2006 Sep; 25(3):499-509. View in: PubMed

  43. Mach J, Hshieh T, Hsieh D, Grubbs N, Chervonsky A. Development of intestinal M cells. Immunol Rev. 2005 Aug; 206:177-89. View in: PubMed

  44. Logunova NN, Viret C, Pobezinsky LA, Miller SA, Kazansky DB, Sundberg JP, Chervonsky AV. Restricted MHC-peptide repertoire predisposes to autoimmunity. J Exp Med. 2005 Jul 04; 202(1):73-84. View in: PubMed

  45. Murphy KT, Wardak A, Beckett MA, Lopez CA, Mehta N, Kimchi E, Salloum RM, Jaskowiak NT, Posner MC, Ohno T, Kufe DW, Weichselbaum RR, Mauceri HJ. Forphenicinol enhances the antitumor effects of cyclophosphamide in a model of squamous cell carcinoma. Cancer Chemother Pharmacol. 2005 Sep; 56(3):317-21. View in: PubMed

  46. Tumanov AV, Kuprash DV, Mach JA, Nedospasov SA, Chervonsky AV. Lymphotoxin and TNF produced by B cells are dispensable for maintenance of the follicle-associated epithelium but are required for development of lymphoid follicles in the Peyer's patches. J Immunol. 2004 Jul 01; 173(1):86-91. View in: PubMed

  47. Pobezinskaya Y, Chervonsky AV, Golovkina TV. Initial stages of mammary tumor virus infection are superantigen independent. J Immunol. 2004 May 01; 172(9):5582-7. View in: PubMed

  48. Christen U, Darwiche R, Thomas HE, Wolfe T, Rodrigo E, Chervonsky A, Flavell RA, von Herrath MG. Virally induced inflammation triggers fratricide of Fas-ligand-expressing beta-cells. Diabetes. 2004 Mar; 53(3):591-6. View in: PubMed

  49. Schott WH, Haskell BD, Tse HM, Milton MJ, Piganelli JD, Choisy-Rossi CM, Reifsnyder PC, Chervonsky AV, Leiter EH. Caspase-1 is not required for type 1 diabetes in the NOD mouse. Diabetes. 2004 Jan; 53(1):99-104. View in: PubMed

  50. Jude BA, Pobezinskaya Y, Bishop J, Parke S, Medzhitov RM, Chervonsky AV, Golovkina TV. Subversion of the innate immune system by a retrovirus. Nat Immunol. 2003 Jun; 4(6):573-8. View in: PubMed

  51. Savinov AY, Wong FS, Stonebraker AC, Chervonsky AV. Presentation of antigen by endothelial cells and chemoattraction are required for homing of insulin-specific CD8+ T cells. J Exp Med. 2003 Mar 03; 197(5):643-56. View in: PubMed

  52. Purdy A, Case L, Duvall M, Overstrom-Coleman M, Monnier N, Chervonsky A, Golovkina T. Unique resistance of I/LnJ mice to a retrovirus is due to sustained interferon gamma-dependent production of virus-neutralizing antibodies. J Exp Med. 2003 Jan 20; 197(2):233-43. View in: PubMed

  53. Savinov AY, Tcherepanov A, Green EA, Flavell RA, Chervonsky AV. Contribution of Fas to diabetes development. Proc Natl Acad Sci U S A. 2003 Jan 21; 100(2):628-32. View in: PubMed

  54. Hook LM, Jude BA, Ter-Grigorov VS, Hartley JW, Morse HC, Trainin Z, Toder V, Chervonsky AV, Golovkina TV. Characterization of a novel murine retrovirus mixture that facilitates hematopoiesis. J Virol. 2002 Dec; 76(23):12112-22. View in: PubMed

  55. Tumanov A, Kuprash D, Lagarkova M, Grivennikov S, Abe K, Shakhov A, Drutskaya L, Stewart C, Chervonsky A, Nedospasov S. Distinct role of surface lymphotoxin expressed by B cells in the organization of secondary lymphoid tissues. Immunity. 2002 Sep; 17(3):239-50. View in: PubMed

  56. Savinov AY, Wong FS, Chervonsky AV. IFN-gamma affects homing of diabetogenic T cells. J Immunol. 2001 Dec 01; 167(11):6637-43. View in: PubMed

  57. Golovkina T, Agafonova Y, Kazansky D, Chervonsky A. Diverse repertoire of the MHC class II-peptide complexes is required for presentation of viral superantigens. J Immunol. 2001 Feb 15; 166(4):2244-50. View in: PubMed

  58. Chervonsky AV. Apoptotic and effector pathways in autoimmunity. Curr Opin Immunol. 1999 Dec; 11(6):684-8. View in: PubMed

  59. Golovkina TV, Shlomchik M, Hannum L, Chervonsky A. Organogenic role of B lymphocytes in mucosal immunity. Science. 1999 Dec 03; 286(5446):1965-8. View in: PubMed

  60. Chervonsky AV, Medzhitov RM, Denzin LK, Barlow AK, Rudensky AY, Janeway CA. Subtle conformational changes induced in major histocompatibility complex class II molecules by binding peptides. Proc Natl Acad Sci U S A. 1998 Aug 18; 95(17):10094-9. View in: PubMed

  61. Tan LJ, Ceman S, Chervonsky A, Rodriguez-Paris J, Steck TL, Sant AJ. Late events in the intracellular sorting of major histocompatibility complex class II molecules are regulated by the 80-82 segment of the class II beta chain. Eur J Immunol. 1997 Jun; 27(6):1479-88. View in: PubMed

  62. Janeway CA, Chervonsky AV, Sant'Angelo D. T-cell receptors: is the repertoire inherently MHC-specific? Curr Biol. 1997 May 01; 7(5):R299-300. View in: PubMed

  63. Chervonsky AV, Wang Y, Wong FS, Visintin I, Flavell RA, Janeway CA, Matis LA. The role of Fas in autoimmune diabetes. Cell. 1997 Apr 04; 89(1):17-24. View in: PubMed

  64. Golovkina TV, Chervonsky A, Prescott JA, Janeway CA, Ross SR. The mouse mammary tumor virus envelope gene product is required for superantigen presentation to T cells. J Exp Med. 1994 Feb 01; 179(2):439-46. View in: PubMed

  65. Chervonsky AV, Gordon L, Sant AJ. A segment of the MHC class II beta chain plays a critical role in targeting class II molecules to the endocytic pathway. Int Immunol. 1994 Jul; 6(7):973-82. View in: PubMed

  66. Stebbins CC, Loss GE, Elias CG, Chervonsky A, Sant AJ. The requirement for DM in class II-restricted antigen presentation and SDS-stable dimer formation is allele and species dependent. J Exp Med. 1995 Jan 01; 181(1):223-34. View in: PubMed

  67. Chervonsky A, Sant AJ. In the absence of major histocompatibility complex class II molecules, invariant chain is translocated to late endocytic compartments by autophagy. Eur J Immunol. 1995 Apr; 25(4):911-8. View in: PubMed

  68. Chervonsky AV, Golovkina TV, Ross SR, Janeway CA. Differences in the avidity of TCR interactions with a superantigenic ligand affect negative selection but do not allow positive selection. J Immunol. 1995 Dec 01; 155(11):5115-23. View in: PubMed

  69. Chervonsky AV, Xu J, Barlow AK, Khery M, Flavell RA, Janeway CA. Direct physical interaction involving CD40 ligand on T cells and CD40 on B cells is required to propagate MMTV. Immunity. 1995 Jul; 3(1):139-46. View in: PubMed

  70. Brondz BD, Karaulov AV, Chervonsky AV, Blandova ZK. Requirement for the location of both appropriate and irrelevant H-2 antigens on the same stimulator cell for unspecific DNA-synthesis inhibition by the H-2-antigen-primed, specific suppressor T cells. Immunogenetics. 1982; 15(2):167-76. View in: PubMed

  71. Brondz BD, Abronina IF, Zaiceva MB, Filatov AV, Chervonsky AV. Specific suppressor T-cells immune to antigens of the H-2 complex: receptors, clonal structure, genetic restriction and antigenic markers. Immunol Rev. 1984 Aug; 80:29-76. View in: PubMed

  72. Brondz BD, Kahn ES, Chervonsky AV, Isakova VR, Apasov SG, Blandova ZK. Differential genetic requirements for in vivo and in vitro induction of T-killer and T-suppressor cells in the mutant H-2Kb system and the cross-reactivity of the T-killer clones. Exp Clin Immunogenet. 1987; 4(4):211-21. View in: PubMed

  73. Neyfakh AA, Serpinskaya AS, Chervonsky AV, Apasov SG, Kazarov AR. Multidrug-resistance phenotype of a subpopulation of T-lymphocytes without drug selection. Exp Cell Res. 1989 Dec; 185(2):496-505. View in: PubMed

  74. Chervonsky AV, Faerman AI, Evdonina LV, Jazova AK, Kazarov AR, Gussev AI. A simple metabolic system for selection of hybrid hybridomas (tetradomas) producing bispecific monoclonal antibodies. Mol Immunol. 1988 Sep; 25(9):913-5. View in: PubMed

  75. Cherapakhin VV, Chervonsky AV, Filatov AV, Rokhlin OV. Monoclonal antibodies against common and Igk-1a allotypic determinants of rat immunoglobulin kappa chain constant domain. Immunol Lett. 1985; 10(3-4):217-21. View in: PubMed

  76. Fedoseyeva EV, Apasov SG, Chervonsky AV. Specific T suppressors and cytotoxic T lymphocytes recognize different epitopes on Abbm12 molecule. Immunogenetics. 1990; 32(2):129-33. View in: PubMed

  77. Golovkina TV, Chervonsky A, Dudley JP, Ross SR. Transgenic mouse mammary tumor virus superantigen expression prevents viral infection. Cell. 1992 May 15; 69(4):637-45. View in: PubMed